Lysine Requirement of Healthy, School-Aged Indian Children Determined by the Indicator Amino Acid Oxidation Technique  

Oleh:

Pillai, Raja R. ; Elango, Rajavel ; Muthayya, Sumithra ; Ball, Ronald O. ; Kurpad, Anura V. ; Pencharz, Paul B.

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: JN: The Journal of Nutrition vol. 140 no. 01 (Jan. 2010), page 54.

Ketersediaan

Perpustakaan FK Nomor Panggil: J42.K.2010.01 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

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Isi artikel

We recently reported the lysine requirement of school-aged children living in Canada consuming a mixed diet to be 35 mg·kg–1·d–1. Because the majority of children in the world live on cereal-based diets in developing countries, we measured the daily lysine requirement in healthy children living in India and consuming a mostly cereal-based diet. Our objective in this study was to determine the lysine requirement in healthy, school-aged children in the developing world by using the indicator amino acid oxidation method with L-[1-13C] phenylalanine. Six healthy, school-aged children consumed 7 levels of lysine (5, 15, 25, 35, 50, 65, and 80 mg·kg–1·d–1) each in a random order along with an amino acid mixture providing energy and protein intakes of 1.7 x resting energy expenditure and 1.5 g·kg–1·d–1, respectively. The mean lysine requirement was determined by applying a 2-phase linear regression crossover analysis on tracer oxidation (F13CO2) data, which identified a breakpoint (requirement) at minimal F13CO2 in response to the graded lysine intakes. The mean lysine requirements with the upper 95% CI for children were determined to be 33.5 and 46.6 mg·kg–1·d–1, respectively, by breakpoint analysis of the F13CO2 data. The mean lysine requirements of Indian children were almost identical to that of Canadian children (35 mg·kg–1·d–1). There is no evidence for any adaptation in lysine requirements in children from developing countries such as India

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