a-Tocopherol transfer protein inhibition is effective in the prevention of cerebral malaria in mice  

Oleh:

Herbas, Maria S ; Okazaki, Mikiko ; Terao, Eri

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: The American Journal of Clinical Nutrition vol. 91 no. 01 (Jan. 2010), page 200-207.
Topik: HEALTH AND NUTRITION; Gene-nutrient; cerebral malaria (CM); Plasmodium sensitivity

Ketersediaan

Perpustakaan FK Nomor Panggil: A07.K.2010.01 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

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Isi artikel

Background: Nutritional status likely plays an important role in determining the outcome of protozoan infections. Despite the evidence of Plasmodium sensitivity to oxidative stress, the potential role of vitamin E, a free radical scavenger, on the outcome of cerebral malaria (CM) has yet to be elucidated. Objective: To determine the influence of vitamin E on Plasmodium parasite development and murine CM outcome, -tocopherol transfer protein (-TTP), a regulator of vitamin E in the host circulation, was abrogated. Design: -TTP knockout mice were infected with Plasmodium berghei ANKA, and survival rate, parasitemia, brain histologic alterations, and brain barrier permeability were assessed. In addition, mRNA expression of the cytokines and adhesion molecules involved in this neurologic pathology were monitored. Results: -TTP knockout mice infected with P. berghei ANKA did not exhibit any clinical or pathologic signs of CM, and a histologic analysis of the brain tissues in these animals showed no alteration of blood-brain barrier integrity compared with that in control mice. Interestingly, protection of the blood-brain barrier in these infected -TTP knockout mice was lost when dietary supplementation with vitamin E was added to their diet. Moreover, interleukins and adhesion molecule transcripts in the brain of control mice were significantly up-regulated compared with those in the -TTP knockout mice. Conclusion: It appears that a deficiency of -tocopherol in the circulation prevents CM and suggests that -TTP is a putative target for the early prevention of CM.

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