The Sex-Specific Role of Plasma Folate in Mediating the Association of Dietary Quality with Depressive Symptoms  

Oleh:

Beydoun, May A. ; Kuczmarski, Marie T. Fanelli

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: JN: The Journal of Nutrition vol. 140 no. 02 (Feb. 2010), page 338-347.
Topik: HEALTH AND NUTRITION

Ketersediaan

Perpustakaan FK Nomor Panggil: J42.K.2010.01 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

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Isi artikel

Folate deficiency has been implicated in the etiology of unipolar depression. In this study, we attempted to cross-link plasma folate, depressive symptoms, and dietary quality (or dietary intake of folate) together in a comprehensive framework, while examining effect modification of those associations by sex. This was a cross-sectional, population-based study of 1681 participants aged 30–64 y (Healthy Aging in Neighborhoods of Diversity across the Lifespan Study). Participants were administered the Center for Epidemiologic Studies Depression scale (CES-D). Measures of plasma folate and dietary intakes (2 24-h recalls) from which the 2005-Healthy Eating Index (HEI) was computed were available. Multivariate logistic regression and structural equation modeling (SM) were conducted. Compared with the lowest tertile, the middle and uppermost tertiles of plasma folate were associated with a 39–40% reduced odds of elevated CES-D (16) among women [adjusted odds ratio (T3 vs. T1) = 0.60 (95% CI = 0.42–0.86); P = 0.006]. Confounding of this association by HEItotal was noted among both men and women, although dietary folate did not confound this association appreciably. In SM, plasma folate completely mediated the inverse HEItotal-CES-D association among men only, specifically for HEI2 (higher intakes of whole fruits), HEI3 (total vegetables), HEI5 (total grains), HEI6 (whole grains), HEI7 (milk), and HEI12 (lower discretionary energy). Among women, HEItotal and 4 components had an inverse direct effect on CES-D score, suggesting a mechanism that is independent of plasma folate. Depressive symptoms in our study may be alleviated by improving overall dietary quality, with plasma folate playing a potential mediating role only among men.

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