The Natural 13C Abundance of Plasma Glucose Is a Useful Biomarker of Recent Dietary Caloric Sweetener Intake  

Oleh:

Cook, Chad M. ; Alvig, Amy L.

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: JN: The Journal of Nutrition vol. 140 no. 02 (Feb. 2010), page 333-337.
Topik: HEALTH AND NUTRITION

Ketersediaan

Perpustakaan FK Nomor Panggil: J42.K.2010.01 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

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Isi artikel

There is a need for objective biomarkers of dietary intake, because self-reporting is often subject to bias. We tested the validity of a biomarker for the fraction of dietary carbohydrate (CHO) from cane sugar and high fructose corn syrup (C4 sugars) using natural 13C abundance of plasma glucose. In a randomized, single-blinded, crossover design, 5 participants consumed 3 weight-maintaining diets for 7 d, with a 2-wk washout between diet periods. Diets differed in the fraction of total CHO energy from C4 sugars (5, 16, or 32%). During each diet period, blood samples were drawn at hours 0800 and 1600 on d 1, 3, and 5 and at 0800, 1000, 1200, 1400, and 1600 on d 7. The 13C abundance of plasma glucose was analyzed via GC- isotope ratio MS. Within each diet period, 13C abundance of the 0800 fasting glucose did not change from baseline with increasing time during a diet period; however, there was a strong positive correlation (R2 = 0.89) between 13C abundance of the glucose concentration at 1000 on d 7 and the percent of breakfast CHO from C4 sugars. Also, 13C abundance of the combined plasma glucose samples on d 7 demonstrated a strong positive correlation (R2 = 0.90) with the percent of total daily CHO from C4 sugars. The natural 13C abundance of postprandial plasma glucose relative to dietary C4 CHO content was a valid biomarker for contributions of C4 caloric sweeteners from the previous meal.

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