| Lack of sleep and sleep disorder are increasing problems in urban communities at this time, however sleep is important for productivity and health, also plays an important role in learning and memory processing. Prolonged lack of sleep cause a decrease in the neurogenesis in hippocampus, the region where the integration of neuronal circuits new cells took place, this include memory processing and emotional regulation. Research for several decades has shown that new neurons are formed in particular areas in adult mammalian brain, such as the dentate region in hippocampus and subventricular area of the lateral ventricles. Various methods that cause sleep deprivation at experimental animals showed a decrease in cell proliferation in the hippocampus which mechanism is not fully understood and one of them is the result of stress as a side effect of sleep deprivation itself. |