The association between serum testosterone levels and cognitive function of men aged 50 years or more  

Oleh:

Wahjoepramono, Eka Julianta

Jenis: Article from Journal - ilmiah nasional - terakreditasi DIKTI
Dalam koleksi: Medical Journal of Indonesia vol. 18 no. 01 (Jan. 2009), page 36-40.
Topik: Testosterone; Cognitive function

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Perpustakaan FK Nomor Panggil: M35.K.02 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

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Aim: The Aging process is a major risk factor for the development of degenerative diseases, including cognitive impairment. Many studies have shown that reduced cognitive function is associated with low testosterone levels. This study was aimed to know the association between serum testosterone level and cognitive functions in men who showed mild cognitive impairrnent. Method: This was a cross-sectional study in men aged SO years or more in Neuroscience Clinic Siloam Hospitals, Lippo Karawaci, Tangerang between 2002 and 2004. Subjects were patients who complained of decreasing cognitive function. Cognitive function was assessed by using the 30-point Mini-Mental State Examination (MMSE) questionnaires. Testosterone level was measured by using the enzyme-linked fluorescent assay (ELFA) method. Results: A total of 112 men were recruited during the study period. The median age was 64 years old. One-hundred and one subjects underwent cognitive function test and serum testosterone assay. The mean MMSE score was 26 + 3.2 points, whereas the mean testosterone level was 14.7 + 5.72 nmol/L. Conclusion: There was no significant correlation between the MMSE score and testosterone level (r=0,038). This sbudy showed that men aged 50 years and above with symptoms of declined cognitive fi~nction have decreasing MMSE scores but were still within the normal range of testosterone levels. No correlation was found between MMSE scores and testosterone levels since most subjects were eugonadal.

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