Type B Gelatin Gel Strength in Granule Formulation and its Mucoadhesive Characteristics  

Oleh:

Suryani, Nelly ; Sulistiawati, Farida ; Fajriani, Astri

Jenis: Article from Journal - ilmiah nasional - terakreditasi DIKTI
Dalam koleksi: Makara Seri Kesehatan vol. 13 no. 1 (Jun. 2009), page 1.
Topik: Gel Strength; Gelatin; Mucoadhesive Granules

Ketersediaan

Perpustakaan Pusat (Semanggi) Nomor Panggil: MM75.2 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

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Isi artikel

Mucoadhesive test ofpolymer excipient is important for development of oral sustained release dosage form in mucoadhesive system toincrease bioavailability of a drug. The study focused on mucoadhesive strength of gelatinus granules in stomach andintestine of rat using bioadhesive and wash off tests. Gelatin is a substance obtained from partially hydrolyzed collagenof skin, white cattle bones and animal bones. Gelatin derived from acid process is called type A gelatin and those fromalkali process is called type B gelatin. This research studied the influence of various gel strength of type B gelatins,particularly their mucoadhesive characteristics. Mucoadhesive tests were performed at the concentration of 7.14%,3.66%, and 2.45% and with gel strength of 328 g Bloom, 230 g Bloom and 119 g Bloom respectively. The resultsshowed that granules formula with 230 g Bloom gel strength showed the best mucoadhesive strength, with adhesionpercentage of 100%.

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