Neuro-Protection and Neuro-Therapy Effects of Acalypha indica Linn. Water Extract Ex Vivo on Musculus gastrocnemius Frog  

Oleh:

Purwaningsih, Ernie H. ; Ibrahim, Nurhadi ; Zain, Hamdani ; Tedjo, Arjo

Jenis: Article from Journal - ilmiah nasional - terakreditasi DIKTI
Dalam koleksi: Makara Seri Kesehatan vol. 12 no. 2 (Dec. 2008), page 70.
Topik: Neuro-protection; Neuro-therapy; Acalypha indica Linn. Ex Vivo

Ketersediaan

Perpustakaan Pusat (Semanggi) Nomor Panggil: MM75.1 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

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Isi artikel

The studies of neuro-protection and neuro-therapy effects of Acalypha indica Linn. water extract ex vivo on m.Gastrocnemius frog have already done at three Departments in Faculty of Medicine, University of Indonesia. Theexperimental studies were done on 2 groups of frog for neuro-protection and neuro-therapy effects. Each group of frogwas divided into 7 subgroups of application, 4 samples each. There were 5 subgroups of doses: 5; 10; 15; 20; 25 mg and2 subgroups as control. Pancuronium bromide 0.2 %, 4 mg, was used for a positive control as muscle relaxant. Neuroprotectionstudy was done as follow: ringer - extract - pancuronium bromide, and neuro-therapy study was ringer -pancuronium bromide - extract, respectively. The parameters measured in these studies were the electrical activitiessuch as amount and duration (second) of re-polarization; depolarization, resting potential, and the height of spike afterelectrical stimulation at 5 mV. Neuro-protection effect of extract was determined by the ability of muscle to show theelectrical response after incubating with pancuronium bromide for 10 minutes, and after incubating with extract for 10minutes for neuro-therapy effect. In the dose of 15 mg and 20 mg/mL of Acalypha indica Linn. extract showed betteractivities than the dose of 25 mg of extract, both as neuro-protection and neuro-therapy effects, but statistically its havenot a significant difference. This study should be followed by an in vivo experiment on frog and it would be done inpharmacokinetic and pharmacodynamic studies on other animal models.

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