Oral prednisolone is an effective adjuvant therapy for acute otitis media with discharge through tympanostomy tubes  

Oleh:

Ruohola, Aino ; Heikkinen, Terho ; Jero, Jussi ; Puhakka, Tuomo ; Juven, Taina

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: The Journal of Pediatrics vol. 135 no. 01 (Jul. 1999), page 459-463.
Topik: AOM ; Acute otitis media; MEE ; Middle ear effusion; OME ; Otitis media with effusion

Ketersediaan

Perpustakaan FK Nomor Panggil: J45.K.1999.02 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

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Isi artikel

Objective: To determine the efficacy of a short course of oral prednisolone as an adjuvant therapy for acute otitis media draining through tympanostomy tubes. Study design: In a randomized, double-blind, placebo-controlled study, children with acute discharge (<48 hours) through tympanostomy tubes received either prednisolone (2 mg/kg/d; n = 23) or placebo (n = 27) for 3 days. All children received amoxicillin/clavulanate (40/10 mg/kg/d) for 7 days. The children were examined daily at the study clinic until the drainage ceased. Results: The median duration of otorrhea in the prednisolone group was 1.0 days (25% to 75% range, 1.0 to 2.0 days), compared with 3.0 days (25% to 75% range, 2.0 to 4.0 days) in the children receiving placebo (P < .001). The duration of otorrhea was =2 days in 21 (91%) children in the prednisolone group, compared with 8 (30%) children in the placebo group (P < .001). Conclusions: Oral prednisolone appears to be modestly effective adjuvant therapy for acute otitis media with discharge through tympanostomy tubes in children. Further studies seem warranted to determine whether short-term use of steroids early during the course of acute otitis media would also reduce the duration of middle ear effusion in children with intact tympanic membranes.

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