Adrenal suppression in children with the human immunodeficiency virus treated with megestrol acetate  

Oleh:

Stockheim, Janet A. ; Daaboul, Jorge J. ; Yogev, Ram ; Scully, Susan P. ; Binns, Helen J. ; Chadwick, Ellen Gould

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: The Journal of Pediatrics vol. 134 no. 3 (Mar. 1999), page 368-370.
Topik: AIDS ; Acquired immunodeficiency syndrome; CDC ; Centers for Disease Control and Prevention; HIV ; Human immunodeficiency virus; IV ; Intravenous; MA ; Megestrol acetate

Ketersediaan

Perpustakaan FK Nomor Panggil: J45.K Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

Lihat Detail Induk

Isi artikel

Symptoms and laboratory evidence of adrenal suppression developed in 2 children with the human immunodeficiency virus after megestrol acetate (MA) therapy was discontinued; both required transient glucocorticoid replacement therapy. High-dose corticotropin stimulation testing performed on children with the human immunodeficiency virus treated or not treated with MA showed that baseline and post-corticotropin cortisol levels were extremely low in 7 of 10 treated patients and normal in 10 of 10 members of a control group (P < .01). MA may suppress adrenal function, and replacement glucocorticoids may prevent or relieve associated symptoms at times of severe stress or on discontinuation of MA therapy.

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