Pediatric liver transplantation with cadaveric or living related donors: Comparative results in 90 elective recipients of primary grafts  

Oleh:

Reding, Raymond ; Goyet, Jean de Ville de ; Delbeke, Isabelle ; Sokal, Etienne ; Jamart, Jacques

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: The Journal of Pediatrics vol. 134 no. 3 (Mar. 1999), page 280-286.
Topik: AR ; Acute rejection; Cad ; Cadaveric; CyA ; Cyclosporin A; CyA-ME ; CyA microemulsion; HLA ; Human leukocyte antigen; LR ; Living-related; OLT ; Orthotopic liver transplantation; PTLD ; Post-transplant lymphoproliferativedisorder; Tac ; Tacrolimus

Ketersediaan

Perpustakaan FK Nomor Panggil: J45.K Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

Lihat Detail Induk

Isi artikel

Study design: Between July 1993 and March 1997, 110 children were listed for primary elective liver transplantation with cadaveric (Cad: n = 68) or living-related (LR: n = 42) donors. Pregraft mortality, post-transplant survival, and surgical and immunologic complications were retrospectively compared in both groups. Results: The pregraft mortality rate was 10 (15%) of 68 versus 1 (2%) of 42 in the Cad and LR groups, respectively (P = .049). Postliver transplantation 1-year patient and graft survival rates were 87% and 75% in the Cad group (n = 49) versus 92% and 90% in the LR group (n = 41), respectively (NS). The incidence of post-transplant complications was as follows: hepatic artery thrombosis (Cad: 16%; LR: 0%, P = .020), portal vein thrombosis (Cad: 8%; LR: 2%, NS), and biliary complications (Cad: 14%; LR: 34%, P = .044). The overall incidence of acute rejection was similar in both groups; however, a lower incidence of acute rejection occurred in LR graft recipients treated with tacrolimus. Conclusions: The introduction of an LR donor liver transplantation program allowed a significant decrease in the pretransplant mortality rate, with a consequent overall improvement in patient survival compared with the Cad series. The incidence of biliary complications was higher in the LR series, whereas better human leukocyte antigen matching in this subgroup did not result in a lower rejection incidence.

Opini Anda

Klik untuk menuliskan opini Anda tentang koleksi ini!

Kembali