Gamma/Delta T-cell Receptor Type Granular Lymphocyte Proliferative Disorder Associated with Rheumatoid Arthritis  

Oleh:

Zenibayashi, M. ; Saigo, K. ; Chayahara, N. ; Sakamoto, Y. ; Inujima, K.

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: The Journal of International Medical Research vol. 33 no. 05 (Sep. 2005), page 583-589.
Topik: T granular lymphocyte proliferative disorder; rheumatoid arthritis

Ketersediaan

Perpustakaan FK Nomor Panggil: J11.K.05-06.01 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

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Isi artikel

We present here a case report of a 69-year-old female patient with T granular lymphocyte proliferative disorder (T-GLPD) expressing the gamma/delta T-cell receptor. The patient had been treated for rheumatoid arthritis for 25 years, and presented with mild anaemia. Cell-surface marker analysis was carried out using flow cytometry and natural killer function was determined using a chromium release assay. The case report is followed by a summary of the 21 other gamma/delta T-GLPD cases reported in the literature and a comparison of their clinical characteristics with those of T-GLPD cases expressing the alpha/beta T-cell receptor. The clinical symptoms and the frequency of association with rheumatoid arthritis are similar in gamma/delta and alpha/beta T-GLPD, but a prevalence of the CD8– cell-surface marker and enhanced natural killer function appear to be characteristics of gamma/delta T-GLPD.

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