Effectiveness of a 23-valent Polysaccharide Vaccine in Preventing Pneumonia and Non-invasive Pneumococcal Infection in Elderly People: a Large-scale Retrospective Cohort Study  

Oleh:

Ansaldi, F. ; Turello, V. ; Lai, P. ; Bastone, G. ; Luca, S. De

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: The Journal of International Medical Research vol. 33 no. 05 (Sep. 2005), page 490-500.
Topik: 23-valent Polysaccharide Vaccine; pneumonia; Non-invasive Pneumococcal

Ketersediaan

Perpustakaan FK Nomor Panggil: J11.K.05-06.01 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

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Isi artikel

This retrospective cohort study evaluated the effectiveness of a 23-valent pneumococcal polysaccharide vaccine in reducing hospital admission for pneumonia, otitis media and exacerbation of asthma or other syndromes due to Streptococcus pneumoniae in 9170 high-risk individuals. Cohort members were followed from 1 January 1998 to 31 December 2002. With regard to preventing hospitalization due to pneumonia, we observed a decrease in the incidence of 1/10000 person-months and a reduction in the relative risk of 38% in the vaccinated cohort compared with the non-vaccinated subjects. A decrease in the risk of hospital admission for asthma, acute otitis media, chronic obstructive pulmonary disease and other respiratory infections was also observed in vaccinated compared with non-vaccinated subjects. The specificity of these findings was confirmed by the lack of a protective effect from vaccination for those outcomes, such as hospitalization ‘for all causes’ and ‘other otorhinolaryngological diagnoses’, that were not directly related to pneumococcal disease.

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