Insulin with Chondroitinase ABC Treats the Rat Model of Acute Spinal Cord Injury  

Oleh:

Yang, Y.-G. ; Jiang, D.-M. ; Quan, Z.-X. ; Ou, Y.-S.

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: The Journal of International Medical Research vol. 37 no. 04 (Jul. 2009), page 1097-1107.
Topik: Insulin; chondroitinase ABC; acute spinal cord injury; rat model; axon regrowth; growth associated protein 43

Ketersediaan

Perpustakaan FK Nomor Panggil: J11.K.2009.02 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

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Isi artikel

Traumatic brain injury is often associated with acute spinal cord injury (ASCI). Insulin and chondroitinase ABC (ChABC) are both therapeutically effective, but the combined therapeutic effect of insulin and ChABC is still not clear. A combination of insulin and ChABC were used to treat a rat model of ASCI. This combination therapy prevented neuronal cell death by improving motor function, increasing cell growth and inhibiting cell apoptosis in ASCI rats. Expression of growth-associated protein 43, a marker of axonal re-growth, increased after combined treatment with insulin and ChABC. These results may provide a basis for a future method of treating ASCI.

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