Effects of Thiopental on Endothelium-dependent Relaxation in Porcine Coronary Arteries  

Oleh:

Dagtekin, O. ; Gerbershagen, H.J. ; Ozgur, E. ; Gaertner, J.

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: The Journal of International Medical Research vol. 37 no. 04 (Jul. 2009), page 1011-1017.
Topik: Endothelium-dependent relaxation; thiopental; anaesthetics; bradykinin; vasolidation; endothelial function; endothelium-derived hyperpolarizing factor

Ketersediaan

Perpustakaan FK Nomor Panggil: J11.K.2009.02 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

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Isi artikel

This study investigated the effects of thiopental on endothelium-dependent relaxation (EDR), and especially the effects on nitric oxide- and prostacyclin-independent EDR. Fresh porcine coronary artery rings (4 mm long), were consecutively tested with and without 20 ìg/ml thiopental in Krebs–Henseleit solution. Indomethacin (10 ìmol/l) was used in all experiments to eliminate prostacyclin effects. Prostaglandin F2alpha (10 micromol/l) was used to induce contractions and bradykinin (10–10 – 10–5 M) was used to induce EDR. Experiments were also carried out using 300 micromol/l N-nitro-l-arginine to block nitric oxide production and to assess the influence of thiopental on nitric oxide- and prostacyclin-independent EDR. Thiopental induced statistically significant increases in EDR at concentrations of 10–6 – 10–5 M bradykinin. Following nitric oxide production block, thiopental significantly reduced the relaxation response at concentrations of 10–8 – 10–5 M bradykinin. At a clinically relevant concentration of 20 microg/ml thiopental, a significant increase in EDR and a significant reduction in nitric oxide- and prostacyclin-independent relaxation was observed in porcine epicardial coronary arteries

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