Y chromosome gr/gr deletions are a risk factor for low semen quality  

Oleh:

Visser, L. ; Westerveld, G.H. ; Korver, C.M. ; Daalen, S.K.M. van

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: Human Reproduction vol. 24 no. 10 (Oct. 2009), page 2667-2673.
Topik: Y chromosome gr; gr deletion; spermatogenesis; semen quality; male infertility

Ketersediaan

Perpustakaan FK Nomor Panggil: H07.K.2009.03 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

Lihat Detail Induk

Isi artikel

BACKGROUND: Subfertility affects one in eight couples. In up to 50% of cases, the male partner has low semen quality. Four Y chromosome deletions, i.e. Azoospermia factor a (AZFa), P5/proximal-P1 (AZFb), P5/distal-P1 and AZFc deletions, are established causes of low semen quality. Whether a recently identified partial AZFc deletion, the gr/gr deletion, also causes low semen quality is at present unclear. METHODS: We used a dual approach to review the effect of the gr/gr deletion on semen quality. First, we conducted a systematic review and meta-analysis of previous association studies, to compare the prevalence of gr/gr deletions between azoo-/oligozoospermic men and normozoospermic men. Secondly, we studied a cohort of 1041 male partners of subfertile couples unselected for semen quality. We employed a cross-sectional design by screening all men for the gr/gr deletion and comparing the semen quality of men with and without the gr/gr deletion. RESULTS: Seven studies were included in the meta-analysis. The gr/gr deletion was significantly more prevalent among azoo-/oligozoospermic men than among normozoospermic men (OR 2.4, 95% CI 1.75–3.30). In our cohort, 25 men carried a gr/gr deletion. Men with this genotype had a lower sperm concentration (median 34 x 106/ml versus 53 x 106/ml, P = 0.017), total sperm count (median 108 x 106 versus 152 x 106, P = 0.006) and total motile sperm count (median 20 x 106 versus 50 x 106, P = 0.010) than men without the gr/gr deletion. CONCLUSION: Y chromosome gr/gr deletions significantly reduce sperm counts and are thus associated with low semen quality.

Opini Anda

Klik untuk menuliskan opini Anda tentang koleksi ini!

Kembali