Karsinoma serviks serta peran dari human papiloma virus.  

Oleh:

Suryawinata, Kidyarto

Jenis: Article from Journal - ilmiah nasional - tidak terakreditasi DIKTI - atma jaya
Dalam koleksi: Majalah Kedokteran Damianus vol. 08 no. 03 (Sep. 2009), page 145-149.
Topik: Squamous Cell Carcinoma; Cervical Intraepithelial Neoplasma; Human Papilloma Virus
Fulltext: D01 v8 n3 p145 kelik2023.pdf (3.35MB)

Ketersediaan

Perpustakaan PKPM Nomor Panggil: M61 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada	Lihat Detail Induk
Perpustakaan FK Nomor Panggil: D01.K Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada	Lihat Detail Induk

Isi artikel

Most of cervical cancers are squamous cell carcinoma (85-90%) and the rest are adenocarcinomas. Squamous cell carcinoma (SCC) is preceded by precancerous lesion, which develop through several grades Cervical Intraepithelial Neoplasia (CIN) 1-3. Human Papilloma Virus (HPV), a sexually transmitted agent is ethiological in the patogenesis of CIN and SCC. Two genes in HPV called E6 and E7 genes, produce proteins that can attach themselves to p53 and Rb which are tumor suppressor proteins that regulate the cell cycle. So when this happens, the infected cells reproduce without any control, they develop permanent changes in their genetic structure that cannot be repaired and some may eventually turn into cancer cells. World Health Organization (WHO) has recognized HPV types 16 and 18 as carcinogenic agents for human.

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