Cardiomyocyte Renewal  

Oleh:

Parmacek, Michael S. ; Epstein, Jonathan A.

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: The New England Journal of Medicine (keterangan: ada di Proquest) vol. 361 no. 01 (Jul. 2009), page 86-88 .
Topik: Cardiomyocyte

Ketersediaan

Perpustakaan FK Nomor Panggil: N08.K.2009.04 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

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Isi artikel

The capacity of the heart to regenerate functional myocardium is extremely limited or absent. This lack of regenerative capacity contrasts with that of many other organs and tissues. Heart failure remains the leading cause of hospitalization in the United States, and its prevalence continues to grow as the population ages. In most patients, the underlying cause of heart failure is a loss of cardiomyocytes, accompanied by functional derangements in contraction and relaxation. The traditional view has held that the reparative ability of the heart is limited by the inability of terminally differentiated cardiomyocytes to undergo cell division after the first weeks of life and a failure in the mobilization of cardiac stem cells (if they exist). However, a recent study by Bergmann and colleagues1 calls this time-tested view into question.

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