Diabetes Complications and the Renin–Angiotensin System  

Oleh:

Perkins, Bruce A. ; Aiello, Lloyd Paul ; Krolewski, Andrzej S.

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: The New England Journal of Medicine (keterangan: ada di Proquest) vol. 361 no. 01 (Jul. 2009), page 83-85.
Topik: Renin–Angiotensin System

Ketersediaan

Perpustakaan FK Nomor Panggil: N08.K.2009.04 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

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Isi artikel

The hypothesis that inhibition of the renin–angiotensin system may be effective in preventing diabetic nephropathy was based on a large body of evidence. Positive findings from studies in animal models and subsequent clinical trials fostered enthusiastic hope that systematic use of agents blocking the renin–angiotensin system in the management of diabetic nephropathy would reduce the risk of end-stage renal disease. Out of such studies was born a concept that gained wide acceptance: inhibition of the renin–angiotensin system in patients with diabetes is beneficial with regard to both early and advanced stages of nephropathy. As an extension, studies were initiated to investigate the mechanism and role of inhibition of the renin–angiotensin system in other complications of diabetes, such as retinopathy and neuropathy.

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