Rhabdomyolysis and Acute Kidney Injury  

Oleh:

Bosch, Xavier ; Poch, Esteban ; Grau, Josep M.

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: The New England Journal of Medicine (keterangan: ada di Proquest) vol. 361 no. 01 (Jul. 2009), page 62-72 .
Topik: Rhabdomyolysis; Acute Kidney Injury

Ketersediaan

Perpustakaan FK Nomor Panggil: N08.K.2009.04 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

Lihat Detail Induk

Isi artikel

Rhabdomyolysis — literally, the dissolution of striped (skeletal) muscle — is characterized by the leakage of muscle-cell contents, including electrolytes, myoglobin, and other sarcoplasmic proteins (e.g., creatine kinase, aldolase, lactate dehydrogenase, alanine aminotransferase, and aspartate aminotransferase) into the circulation. Massive necrosis, which is manifested as limb weakness, myalgia, swelling, and, commonly, gross pigmenturia without hematuria, is the common denominator of both traumatic and nontraumatic rhabdomyolysis. Acute kidney injury is a potential complication of severe rhabdomyolysis, regardless of whether the rhabdomyolysis is the result of trauma or some other cause, and the prognosis is substantially worse if renal failure develops. In contrast, in less severe forms of rhabdomyolysis or in cases of chronic or intermittent muscle destruction — a condition sometimes called hyperCKemia — patients usually present with few symptoms and no renal failure. We review the pathophysiological characteristics and management of acute kidney injury associated with rhabdomyolysis.

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