Interleukin-17 and Type 17 Helper T Cells  

Oleh:

Miossec, Pierre ; Korn, Thomas ; Kuchroo, Vijay K.

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: The New England Journal of Medicine (keterangan: ada di Proquest) vol. 361 no. 09 (Aug. 2009), page 888-898 .
Topik: Interleukin 17; Type 17 Helper T Cell

Ketersediaan

Perpustakaan FK Nomor Panggil: N08.K Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

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Isi artikel

In 1986, Mosmann and Coffman introduced the concept of distinct types of helper T cells, which was based on the types of cytokines that T cells produce when they are stimulated to differentiate. They named these lymphocytes type 1 helper T cells (Th1 cells) and type 2 helper T cells (Th2 cells). Th1 cells produce large quantities of interferon-{gamma}, induce delayed hypersensitivity reactions, activate macrophages, and are essential for the defense against intracellular pathogens. Th2 cells produce mainly interleukin-4 and are important in inducing IgE production, recruiting eosinophils to sites of inflammation, and helping to clear parasitic infections. These distinctions allowed the assignment of a specific functional phenotype to helper T cells based on the effector cytokines that they produce. The production of effector cytokines underlies the term "effector helper T cells."

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