Platelets, Pyrexia, and Plasmodia  

Oleh:

Greenbaum, Doron C. ; FitzGerald, Garret A.

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: The New England Journal of Medicine (keterangan: ada di Proquest) vol. 361 no. 05 (Jul. 2009), page 526-528 .
Topik: Platelets; Pyrexia; Plasmodia

Ketersediaan

Perpustakaan FK Nomor Panggil: N08.K.2009.04 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

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Isi artikel

Platelets have long been known to interact cooperatively with erythrocytes in thrombogenesis, both generally and in patients with sickle cell disease. Recently, the molecular mechanisms by which neutrophils can bridge their interactions with endothelial cells have begun to be elucidated. A recent study by McMorran et al. raises the possibility that platelet–erythrocyte interactions might be clinically felicitous in patients with malaria. This disease is caused, in humans, by four parasites of the plasmodium genus: Plasmodium falciparum, P. vivax, P. ovale, and P. malariae. P. falciparum malaria is associated with the majority of deaths from malaria worldwide, with children bearing a disproportionate burden. Symptoms associated with severe P. falciparum malaria typically include high fever and metabolic acidosis, as well as associated respiratory distress, anemia, hypoglycemia, seizures, and, in children, both cerebral edema and coma.

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