The Effects of Calcitriol Therapy on Serum Interleukin-1, Interleukin-6 and Tumour Necrosis Factor-a Concentrations in Post-menopausal Patients with Osteoporosis  

Oleh:

Inanir, A. ; Ozoran, K. ; Tutkak, H. ; Mermerci, B.

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: The Journal of International Medical Research vol. 32 no. 06 (Nov. 2004), page 570-582.
Topik: Calcitriol; Interleukin-1; Interleukin-6; Tumour Necrosis Factor-a; post-menopausal; osteoporosis

Ketersediaan

Perpustakaan FK Nomor Panggil: J11.K.01-04.01 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

Lihat Detail Induk

Isi artikel

Seventy post-menopausal women with osteoporosis were randomized into two groups: 40 patients received calcitriol (0.5 µg/day) and calcium (1000 mg/day); and 30 control patients received calcium (1000 mg/day) alone. Thirty healthy women formed the healthy control group. Bone mineral density (BMD) and serum interleukin (IL)-1, IL-6 and tumour necrosis factor-a (TNF-a) concentrations were measured at baseline and after 6 months of treatment. Calcitriol treatment for 6 months significantly increased BMD and reduced serum IL-1 and TNF-a concentrations compared with no significant changes in patients treated with calcium alone. Both treatments increased serum calcium and decreased parathyroid hormone concentrations. The healthy control group had a significantly lower IL-6 concentration than the post-menopausal women with osteoporosis. We have shown that calcitriol was an effective treatment for osteoporosis. Significant reductions in serum IL-1 and TNF-a concentrations suggest that, in addition to increasing the absorption of calcium, calcitriol may directly affect bone metabolism via cytokines.

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