Cortical Expression of Peroxisome Proliferator-activated Receptor-alpha After Human Brain Contusion  

Oleh:

Feng, D. ; Zhang, Y. ; Chen, G.

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: The Journal of International Medical Research vol. 36 no. 04 (Jul. 2008), page 783-791.
Topik: Brain Contusion

Ketersediaan

Perpustakaan FK Nomor Panggil: J11.K.2008.02 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

Lihat Detail Induk

Isi artikel

Recent studies have demonstrated that peroxisome proliferator-activated receptor-alpha (PPAR-alpha) agonists can protect the brain against excessive oxidative stress and inflammation in traumatic brain injury (TBI) and stroke through endogenous PPAR-alpha. However, it has not been investigated whether, and to what degree, cerebral expression of PPAR-alpha changes after TBI, especially in the human brain. In this study, 12 contused brain samples were obtained from 11 patients undergoing surgery for TBI 6 – 98 h after trauma. PPAR-alpha binding activity was measured by electrophoretic mobility shift assay, and temporal and cellular expression of PPAR-alpha by immunohistochemistry. The results showed that a persistent upregulation of PPAR-alpha binding activity and protein expression occurred in injured cortex after TBI, which peaked 24 – 72 h post-injury. Expression of PPAR-alpha was mainly located in glial and vascular endothelial cells with a little expression in the neurons. It is concluded that TBI could greatly upregulate the binding activity and protein expression of PPAR-alpha in injured human brain, which might be important in brain pathophysiology after TBI.

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