Use of 99mTc-Sulesomab for the Diagnosis of Prosthesis Infection after Total Joint Arthroplasty  

Oleh:

Pakos, E.E. ; Fotopoulos, A.D. ; Stafilas, K.S. ; Gavriilidis, I.

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: The Journal of International Medical Research vol. 35 no. 04 (Jul. 2007), page 474-481.
Topik: 99mTc-Sulesomab; prosthesis infection; total joint arthroplasty

Ketersediaan

Perpustakaan FK Nomor Panggil: J11.K.2007.01 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

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Isi artikel

This study aimed to evaluate the diagnostic efficacy of antigranulocyte scintigraphy using the antibody fragment 99mTc-sulesomab (LeukoScan®) for the diagnosis of prosthesis infection in patients with total hip or knee arthroplasty. The results from 19 patients with suspected total joint arthroplasty infection who had undergone a threephase bone scan and a subsequent examination with 99mTc-sulesomab during a 1 year period were reviewed. Twelve patients were shown to have prosthesis infection on culture of aspirated synovial fluid or intra-operative samples. The overall sensitivity, specificity, positive and negative predictive values, and diagnostic accuracy for 99mTc-sulesomab were 75%, 86%, 90%, 66% and 79%, respectively, compared with 54%, 83%, 88%, 45% and 63%, respectively, for the three-phase bone scan. This study showed that 99mTc-sulesomab had good diagnostic value for the detection of prosthesis infection. The combination of 99mTc-sulesomab with other laboratory or imaging examinations may improve diagnostic performance in prosthesis infection and should be investigated further.

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