Serum Anti-Amyloid-beta Antibodies and Alzheimer’s Disease in Elderly Korean Patients  

Oleh:

Song, M.S. ; Mook-Jung, I. ; Lee, H.J. ; Min, J.Y. ; Park, M.H.

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: The Journal of International Medical Research vol. 35 no. 03 (May 2007), page 301-306.
Topik: anti-amyloid-beta antibodies; Alzheimer’s disease

Ketersediaan

Perpustakaan FK Nomor Panggil: J11.K.2007.01 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

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Isi artikel

Alzheimer’s disease (AD) is characterized by the deposition of senile plaques and neurofibrillary tangles in the brain. The presence of the amyloid-beta (A-beta) peptide in senile plaques seems to play a central role in the neuropathology of AD. Diagnosis of AD involves neuropsychological examinations or magnetic resonance imaging and, to date, a specific diagnostic marker indicating AD has not been found. This study analysed anti-A-beta antibodies from the serum of 153 patients with AD using an enzyme-linked immunosorbent assay method. The levels of anti-A-beta antibody from patients in the control group (n = 193) were compared with those of patients with AD. Our results showed a significantly lower anti-A-beta antibody level in patients with AD than in the control group. These results showed that the anti-A-beta antibody level in serum could potentially be used to diagnose the presence of AD.

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