Changes in the Expression of Endothelial-overexpressed Lipopolysaccharide-associated Factor 1 in Grafts during Acute Rejection Following Liver Transplantation in Rats  

Oleh:

Ran, C.F. ; Dou, K. ; Liang, Z. ; Liu, Y. ; Li, K.

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: The Journal of International Medical Research vol. 36 no. 03 (May 2008), page 460-466.
Topik: Liver Transplantation

Ketersediaan

Perpustakaan FK Nomor Panggil: J11.K.2008.01 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

Lihat Detail Induk

Isi artikel

This study investigated changes in expression of endothelial-overexpressed lipopolysaccharide-associated factor 1 (EOLA1) in grafts following liver transplantation in rats. Thirty Lewis rats received liver transplants from Lewis rats (tolerance group); 30 received liver transplants from dark Agouti rats (acute rejection group). Changes in serum biochemical indexes (alanine aminotransferase and total bilirubin), graft histology and EOLA1 expression were measured on days 1, 3, 5, 7 and 10 post-operatively. Mean survival time was over 100 days in the tolerance group and 16.2 ± 1.4 days in the acute rejection group. Pathological evidence of acute rejection in grafts was seen after day 5 in the acute rejection group. Serum biochemical indexes were significantly higher in the acute rejection group than in the tolerance group from day 5 postoperatively, whereas EOLA1 expression in the liver graft was significantly higher in the tolerance group than in the acute rejection group. EOLA1 expression seems to be negatively correlated with severity of rejection after liver transplantation.

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