Influence of Propylthiouracil and Methimazole Pre-treatment on the Outcome of Iodine-131 Therapy in Hyperthyroid Patients with Graves’ Disease  

Oleh:

Shi, G.-M. ; Xu, Q. ; Zhu, C.Y. ; Yang, Y,-L.

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: The Journal of International Medical Research vol. 37 no. 02 (Mar. 2009), page 576-582.
Topik: Propylthiouracil; Methimazole; Graves Disease

Ketersediaan

Perpustakaan FK Nomor Panggil: J11.K.2009.01 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

Lihat Detail Induk

Isi artikel

There is ongoing controversy about potential differences in the influence of the anti-thyroid drugs propylthiouracil (PTU) and methimazole (MMI) on radioiodine treatment of Graves’ hyperthyroidism. This retrospective study investigated the influence of PTU and MMI pre-treatment, individually or sequentially, on the outcome of iodine-131 (131I) therapy in 199 patients with Graves’ disease who had been treated with 131I for the first time and followed up at 3 and 6 months after treatment. Pre-treatment with PTU, or sequential PTU and MMI pre-treatment, increased the failure rate of 131I therapy and reduced the rate of hypothyroidism. MMI pre-treatment alone had no significant influence on the results of 131I therapy. Logistic regression analyses indicated that PTU pre-treatment and having a thyroid gland of > 60 g were both significantly related to 131I therapy failure.

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