Serial Measurements of Cystatin C Are More Accurate Than Creatinine-Based Methods in Detecting Declining Renal Function in Type 1 Diabetes  

Oleh:

Premaratne, Erosha ; MacIsaac, Richard J. ; Finch, Sue ; Panagiotopoulos, Sianna

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: Diabetes Care vol. 31 no. 05 (May 2008), page 971-973.
Topik: Cystatin C; Creatinine

Ketersediaan

Perpustakaan FK Nomor Panggil: D05.K.2008.02 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

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Isi artikel

OBJECTIVE—Cystatin C–and creatinine-based methods were compared with 99m-technetium-diethylene-triamine-penta-acetic acid (99mTc-DTPA) plasma clearance (isotopic glomerular filtration rate [iGFR]) for detecting declining renal function. RESEARCH DESIGN AND METHODS—Glomerular filtration rate (GFR) was monitored over a mean of 10.1 years in 85 subjects with type 1 diabetes (with an average of 5.6 measurements per individual). Baseline mean ± SD iGFR of the cohort was 106.1 ± 2.6 ml/min per 1.73 m2. The rates of decline in GFR (?GFR) were derived using linear regression. RESULTS—In 19 of 85 subjects with declining renal function (i.e., ?iGFR >3.3 ml/min per 1.73 m2 per year), ?GFR (ml/min per 1.73 m2 per year) was 6.5 by iGFR, 4.2 by 104/creatinine, 3.6 by Cockcroft-Gault formula, 3.4 by the Modification of Diet in Renal Disease (MDRD)-6 equation, and 3.5 by the MDRD-4 variable equation (P < 0.01 vs. iGFR). In comparison, ?GFR was 6.1 using the formula Cys-GFR = (86.7/cystatin C concentration) - 4.2 (not significant). CONCLUSIONS—Cystatin C was more accurate in detecting decline in renal function than creatinine-based methods in this population of subjects with type 1 diabetes and a normal mean baseline GFR.

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