CYP11A1 and CYP17 promoter polymorphisms associate with hyperandrogenemia in polycystic ovary syndrome  

Oleh:

Pusalkar, Madhavi ; Meherji, Pervin ; Gokral, Jyotsna ; Chinnaraj, Saravanan

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: Fertility and Sterility (keterangan: ada di ClinicalKey) vol. 92 no. 02 (Aug. 2009), page 653-659.
Topik: CYP11A1; CYP17; PCOS; hyperandrogenemia

Ketersediaan

Perpustakaan FK Nomor Panggil: F02.K.2009.03 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

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Isi artikel

Objective : To analyze promoter regions of CYP11A1 and CYP17 for putative variations in a defined group of women with polycystic ovary syndrome (PCOS) and to study their association with androgen levels. Design : Retrospective study. Setting : A secondary referral center for infertility at National Institute for Research in Reproductive Health, Mumbai, India. Patient(s) : One hundred women whose condition was diagnosed on the basis of the Rotterdam consensus were compared against 100 age-matched controls. Intervention(s) : A single sample of blood was collected after overnight fast on day 3 of the menstrual cycle. Main outcome Measure(s) : Plasma levels of T, androstenedione, 17a-hydroxyprogesterone, and DHEAS and nucleotide sequence of promoter regions of CYP11A1 and CYP17 genes. Result(s) : Polymorphisms in promoter regions of the two key androgen-regulating genes, CYP11A1 and CYP17, were found to be significantly associated with T levels in the cohort of well-characterized PCOS cases as compared with controls. The significance was greater in the PCOS cases with both the polymorphisms. Conclusion(s) : Our study carried out in a defined group of Indian women with PCOS suggests for the first time an individual, as well as combined, association of polymorphisms in CYP11A1 and CYP17 promoters with T levels.

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