Reducing blood loss at myomectomy with use of a gelatin-thrombin matrix hemostatic sealant  

Oleh:

Raga, Francisco ; Sanz-Cortes, Magda ; Bonilla, Francisco ; Casan, Eva Maria

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: Fertility and Sterility (keterangan: ada di ClinicalKey) vol. 92 no. 01 (Jul. 2009), page 356-360.
Topik: Myoma; myomectomy; FloSeal; hemostatic sealant

Ketersediaan

Perpustakaan FK Nomor Panggil: F02.K.2009.03 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

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Isi artikel

Objective : To evaluate the hemostatic efficacy and handling of gelatin-thrombin matrix in abdominal myomectomy. Design : Prospective and randomized trial. Setting : University teaching hospital. Patient(s) : Women (n = 50) with uterine fibroids with a uterine size equivalent to =16 weeks gestation. Intervention(s) : Gelatin-thrombin matrix (FloSeal Matrix; Baxter Healthcare Corp., Fremont, CA) was delivered to the site of the uterine bleeding during myomectomy. Main Outcome Measure(s) : Patient age, parity, number of myomas, operative time, blood loss, transfusion, intraoperative and postoperative complications, and length of hospitalization were evaluated. Result(s) : The average blood loss during surgery was 80 ± 25.5 mL for the FloSeal group and 625 ± 120.5 mL for the control group. Intraoperative blood transfusion was necessary in five patients from the control group. Postoperative blood loss was 25 ± 5 mL for the FloSeal group and 250 ± 75 mL for the control group. Length of the postoperative hospital stay was 2.5 ± 1.2 days for FloSeal group and 4.5 ± 1.3 for the control group. No major immediate or delayed complications were observed in either group. Conclusion(s) : Reductions in hemorrhage in FloSeal-treated women undergoing a myomectomy are encouraging, and provide evidence for the ability of gelatin-thrombin matrix to reduce blood loss when applied immediately and directly to bleeding uterine tissue.

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