Persistence of androgenic effects on the production of proinflammatory cytokines by circulating antigen-presenting cells after withdrawal of testosterone treatment in aging type 2 diabetic men with partial androgen deficiency  

Oleh:

Corrales, Juan Jose ; Almeida, Maria ; Miralles, Jose Manuel ; Orfao, Alberto

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: Fertility and Sterility (keterangan: ada di ClinicalKey) vol. 92 no. 01 (Jul. 2009), page 311-319.
Topik: Dendritic cells; monocytes; testosterone; immune response; inflammatory cytokines; androgens; aging; testosterone deprivation; hypogonadism

Ketersediaan

Perpustakaan FK Nomor Panggil: F02.K.2009.03 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

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Isi artikel

Objective : To test the hypothesis that T treatment withdrawal could be associated with an enhancement of proinflammatory cytokine production by peripheral blood monocytes and dendritic cells. Design : A prospective intervention study. Setting : Tertiary university hospital. Patient(s) : Thirteen type 2 diabetic men aged >55 years with partial androgen deficiency and eight age-matched healthy men (controls). Intervention(s) : Analyses were performed before and 12 months after T replacement therapy and the results compared with those obtained for the same patients after a 3-month T withdrawal period. Main Outcome Measure(s) : Distribution of circulating T, B, and natural killer lymphocytes, monocytes, and CD33hi myeloid, CD16+, and plasmacytoid dendritic cell subsets. Spontaneous and stimulated ex vivo production of inflammatory cytokines (interleukin-1ß, interleukin-6, and tumor necrosis factor-a) by circulating monocytes and dendritic cells, which represent the most potent antigen-presenting cells. Result(s) : The reduction or complete abrogation of spontaneous ex vivo production of proinflammatory cytokines by monocytes and dendritic cells observed after 12 months of T replacement therapy was maintained 3 months after T withdrawal. Conclusion(s) : These are the first results showing that exogenous T treatment deprivation is not associated with an immunologic enhancement of proinflammatory cytokine production by antigen-presenting cells.

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