Comparative effects of atorvastatin and simvastatin on the plasma total homocysteine levels in women with polycystic ovary syndrome: a prospective randomized study  

Oleh:

Kaya, Cemil ; Cengiz, Sevim Dinçer ; Berker, Bülent ; Demirtas, Selda

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: Fertility and Sterility (keterangan: ada di ClinicalKey) vol. 92 no. 02 (Aug. 2009), page 635-642.
Topik: Polycystic ovary syndrome; statin therapy; homocysteine; insulin resistance; testosterone

Ketersediaan

Perpustakaan FK Nomor Panggil: F02.K.2009.03 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

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Isi artikel

Objective : To test the hypothesis that statins improve hyperhomocysteinemia in women with polycystic ovary syndrome (PCOS). Design : A prospective randomized study. Setting : University Hospital. Patient(s) : Fifty-two women with PCOS and 52 women matched for age and body mass index as controls. Intervention(s) : Patients were randomly divided into two groups for treatment: group 1, atorvastatin, 20 mg daily (n = 26), and group 2, simvastatin, 20 mg daily (n = 26). Blood samples were obtained before and after treatment. Main Outcome Measure(s) : Serum homocysteine levels. Result(s) : After 12 weeks of treatment, serum homocysteine levels in group 1 had decreased from 14.3 ± 2.9 to 10.6 ± 1.7 µmol/L; in group 2, the levels decreased from 13.6 ± 2.1 to 11.1 ± 1.9 µmol/L. Both two groups, free testosterone and total testosterone declined statistically significantly (38.3% and 36.5%; and 40.6% and 46.0%, respectively). In group 1, vitamin B12 increased from 362.1 ± 107 to 478.7 ± 267 pg/mL; in group 2, it increased from 391.3 ± 107 to 466 ± 211 pg/mL, but the change did not reach statistical significance. There was a considerable decline in the homeostatic model assessment index in group 1 (40.0% to 32.1%). Conclusion(s) : Treatment with statins in women with PCOS leads to decreases in serum homocysteine levels.

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