Effects of nonoral estradiol–micronized progesterone or low-dose oral estradiol–drospirenone therapy on metabolic variables and markers of endothelial function in early postmenopause  

Oleh:

Casanova, Gislaine ; Radavelli, Simone ; Lhullier, Francisco ; Spritzer, Poli Mara

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: Fertility and Sterility (keterangan: ada di ClinicalKey) vol. 92 no. 02 (Aug. 2009), page 605-612.
Topik: Menopause; cardiovascular disease; HT; endothelium

Ketersediaan

Perpustakaan FK Nomor Panggil: F02.K.2009.03 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

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Isi artikel

Objective : To evaluate the effects of low-dose oral hormone therapy and nonoral hormone therapy on endothelial function markers and on anthropometric, metabolic, and hormonal variables in early postmenopausal women. Design : Cross-over, randomized clinical trial. Setting : Gynecological Endocrinology Unit. Patient(s) : Healthy postmenopausal women. Intervention(s) : Twenty patients received oral E2 1 mg plus drospirenone 2 mg/d for 2 months. Another group of 20 patients received 3 mg/d 17ß intranasal E2, and then 200 mg/d vaginal micronized P for 14 days during two 28-day cycles. At the end of this period, the patients were crossed over for another 2 months. Main Outcome Measure(s) : Endothelial function markers and anthropometric, metabolic, and hormonal variables before and after hormone therapy. Result(s) : Mean age was 51.2 ± 2.7 years. Mean time since menopause was 23.1 ± 10 months. After low-dose treatment, a reduction in waist circumference, waist-to-hip ratio, and high-density-lipoprotein cholesterol was observed. Triglycerides and von Willebrand factor levels decreased significantly with nonoral treatment. Fasting glucose and insulin levels did not change. In both groups, total and non-high-density-lipoprotein cholesterol levels decreased below basal levels, and endothelin-1, fibrinogen, and C-reactive protein levels remained unchanged. Conclusion(s) : Neither treatment induced deleterious effects in the short term on variables related to cardiovascular risk in early postmenopausal women.

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