High serum FSH levels in men with nonobstructive azoospermia does not affect success of microdissection testicular sperm extraction  

Oleh:

Ramasamy, Ranjith ; Lin, Kathleen ; Veeck Gosden, Lucinda ; Rosenwaks, Zev

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: Fertility and Sterility (keterangan: ada di ClinicalKey) vol. 92 no. 02 (Aug. 2009), page 590-593.
Topik: Azoospermia; testis; biopsy; FSH; microdissection; TESE; predictors; pregnancy

Ketersediaan

Perpustakaan FK Nomor Panggil: F02.K.2009.03 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

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Isi artikel

Objective : To evaluate the outcomes of microdissection testicular sperm extraction (micro-TESE) in patients with high FSH. Design : Clinical retrospective study. Setting : Department of urology at a tertiary university hospital. Patient(s) : Seven hundred ninety-two men with nonobstructive azoospermia. Intervention(s) : Micro-TESE followed by intracytoplasmic sperm injection was performed. The men were classified into four groups based on serum FSH levels: <15, 15–30, 31–45, and >45 IU/mL. Main Outcome Measure(s) : Sperm retrieval, clinical pregnancy, and live birth rates. Result(s) : Testicular sperm were successfully retrieved in 60% of the men. Sperm retrieval rates in the groups of men with FSH values 15–30, 31–45, and >45 IU/mL was 60%, 67%, and 60% respectively; this was higher than the group of men with FSH < 15 (51%). Of those men who had sperm retrieved, clinical pregnancy and live birth rates were similar in the four groups (46%, 50%, 52%, 46% and 38%, 45%, 44%, 36%, respectively). Conclusion(s) : The chances of sperm retrieval using micro-TESE is just as common, if not better for men with elevated FSH levels than for men with lower FSH. Micro-TESE results appear to differ from earlier series that report low retrieval rates with random biopsies for men with elevated FSH. High FSH is not a contraindication for micro-TESE.

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