Role of male factor in early recurrent embryo loss: do antioxidants have any effect?  

Oleh:

Gil-Villa, Aura Maria ; Cardona-Maya, Walter ; Agarwal, Ashok ; Sharma, Rakesh ; Cadavid, Angela

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: Fertility and Sterility (keterangan: ada di ClinicalKey) vol. 92 no. 02 (Aug. 2009), page 565-571.
Topik: Spermatozoa; embryo loss; DNA damage; oxidative stress; antioxidants

Ketersediaan

Perpustakaan FK Nomor Panggil: F02.K.2009.03 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

Lihat Detail Induk

Isi artikel

Objective : To evaluate whether increasing antioxidant intake in men with high levels of DNA damage or lipid peroxidation improves gestational results in couples with history of recurrent embryo loss. Design : Descriptive study (case series). Setting : Early recurrent embryo loss program at the University of Antioquia, Medellín, Colombia. Patient(s) : Seventeen men whose spouses had a history of two or more embryo losses before 12 weeks of gestation. Intervention(s) : Male partners with increased DNA fragmentation index (%DFI) or high thiobarbituric acid reactive substances (TBARS) were instructed to consume a diet rich in antioxidants or commercial multivitamins containing ß-carotene, vitamin C, vitamin E, and zinc for at least 3 months. Main Outcome Measure(s) : Pregnancy outcome was recorded in the spouses of men with increased %DFI or TBARS who received antioxidant supplementation. Results : Of the 17 men, 9 (53%) presented with an increased %DFI or TBARS. They were started on an antioxidant supplementation regimen. Of these nine men, six of their spouses became pregnant. All couples whose male partners accepted antioxidant supplementation achieved a successful pregnancy. Conclusions : Our study demonstrates the benefits of an increased intake of antioxidant-rich food or antioxidant supplements by men who show high levels of sperm DNA fragmentation or lipid peroxidation, which could result in an improvement in gestational outcomes in couples with history of recurrent embryo losses.

Opini Anda

Klik untuk menuliskan opini Anda tentang koleksi ini!

Kembali