Association of CYP1A1 and glutathione S-transferase polymorphisms with male factor infertility  

Oleh:

Aydos, Sena Erdogan ; Taspinar, Mehmet ; Sunguroglu, Asuman ; Aydos, Kaan

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: Fertility and Sterility (keterangan: ada di ClinicalKey) vol. 92 no. 02 (Aug. 2009), page 541-547.
Topik: Infertility; CYP1A1; GSTM1; GSTT1; polymorphism

Ketersediaan

Perpustakaan FK Nomor Panggil: F02.K.2009.03 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

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Isi artikel

Objective : To examine whether a relationship exists between genetic polymorphisms of glutathione S-transferase (GST) M1 and T1, CYP1A1*2C, and male factor infertility. Design : Genetic polymorphism analysis, case-control study. Setting : University research laboratory and andrology clinic. Patient(s) : One hundred ten men with infertility and 105 healthy fertile men were recruited for the study. Intervention(s) : Physical examination of the genitalia of patients, scrotal colored Doppler ultrasound examination, and blood sampling were performed for DNA extraction and genotyping. Main Outcome Measure(s) : CYP1A1*2C, GSTM1, and GSTT1 polymorphism genotypes were determined by polymerase chain reaction and restriction fragment length polymorphism methods. Seminal parameters were analyzed. Result(s) : There were significant differences between infertility and GSTM1, CYP1A1*2C genotypes by univariate analyses. A subject carrying CYP1A1 Val/Val or CYP1A1 Ile/Val in association with GSTM null genotype has 6.90 times more risk to be infertile than a subject carrying CYP1A1 Ile/Ile in association with GSTM1 wild-type genotype (odds ratio: 6.90, 95% confidence interval: 2.29–19.3). No correlation was found between the seminal parameters and the genetic variability. Conclusion : Our results suggest that genetic polymorphisms of xenobiotic-metabolizing enzymes could play an important role in infertility.

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