Serum levels of soluble vascular cell adhesion molecule-1, tumor necrosis factor-a, and interleukin-6 in in vitro fertilization cycles  

Oleh:

Souter, Irene ; Huang, Andy ; Martinez-Maza, Otoniel ; Breen, Elizabeth Crabb

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: Fertility and Sterility (keterangan: ada di ClinicalKey) vol. 91 no. 5 Sup (May 2009), page 2012-2019.
Topik: Soluble vascular adhesion molecule-1; tumor necrosis factor-a; interleukin-6; E2; in vitro fertilization

Ketersediaan

Perpustakaan FK Nomor Panggil: F02.K.2009.02 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

Lihat Detail Induk

Isi artikel

Objective : To assess whether gonadotropin-induced changes in E2 alter serum levels of soluble vascular cell adhesion molecule-1 (sVCAM-1) and proinflammatory cytokines. Design : Prospective collection of serum in patients undergoing IVF. Setting : University hospital. Patient(s) : Twenty-four infertile women. Intervention(s) : Serum collection at baseline, in the mid and late follicular phases, at oocyte retrieval, and in the mid and late luteal phases. Main Outcome Measure(s) : Samples were assayed for sVCAM-1, tumor necrosis factor-a (TNF-a), interleukin-6 (IL-6), and E2. Result(s) : The VCAM-1 was maximally suppressed in the luteal phase. Luteal sVCAM-1 levels correlated [1] positively with the patient's age, units of gonadotropins, day 3 FSH levels and [2] negatively with [a] the follicular, retrieval, and luteal E2 levels and [b] the number of preovulatory follicles and oocytes retrieved. Similar correlations were noted in the late luteal phase. Serum TNF-a reached a peak in the mid-follicular phase and a nadir in the luteal phase. The TNF-a levels at retrieval correlated [1] positively with the patient's age and [2] negatively with E2 and number of preovulatory follicles and retrieved oocytes. The IL-6 levels were suppressed in the follicular phase and correlated negatively with E2 levels. Conclusion(s) : Changes in E2 levels seen during gonadotropin stimulation significantly alter VCAM-1 expression and induce changes in serum IL-6 and TNF-a levels.

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