Proportional change of CD4+CD25+ regulatory T cells after lymphocyte therapy in unexplained recurrent spontaneous abortion patients  

Oleh:

Hui, Yang ; Lihua, Qiu ; Wen, Di ; Aiming, Zhao

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: Fertility and Sterility (keterangan: ada di ClinicalKey) vol. 92 no. 01 (Jul. 2009), page 301-305.
Topik: Spontaneous abortion; recurrent abortion; regulatory T cells; leukocyte immunization; pregnancy

Ketersediaan

Perpustakaan FK Nomor Panggil: F02.K.2009.03 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

Lihat Detail Induk

Isi artikel

Objective : To investigate the proportional changes of CD4+CD25+ regulatory T cells in peripheral blood after lymphocyte therapy in unexplained recurrent spontaneous abortion (URSA) patients. Design : Prospective cohort study. Setting : University Hospital. Patient(s) : Twenty-five URSA patients. Intervention(s) : Measurements of CD4+CD25+ regulatory T cells in peripheral blood before and after paternal or third-party lymphocyte immunization. Main Outcome Measure(s) : The proportion of CD4+CD25bright regulatory T cells and the percentage of CD25bright cells in the CD4+ T-cell population. Result(s) : The proportion of CD4+CD25bright T cells in peripheral blood from URSA patients was increased significantly after paternal or third-party lymphocyte immunization therapy, whereas the percentage of CD4+CD25dim cells were decreased significantly. The percentage of CD4+CD25bright cells in the CD4+ T-cell population was significantly increased, and the proportion of CD4+CD25bright T cells was significantly higher in successfully pregnant women than in those with pregnancy loss after lymphocyte therapy. Conclusion(s) : Allogeneic lymphocyte therapy can enhance the percentage of CD4+CD25bright regulatory T cells in peripheral blood, therefore CD4+CD25+ regulatory T cells may serve as a novel biomarker for monitoring allogeneic lymphocyte therapy in URSA patients.

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