A meta-analysis of the route of administration of luteal phase support in assisted reproductive technology: vaginal versus intramuscular progesterone  

Oleh:

Zarutskie, Paul W. ; Phillips, James A.

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: Fertility and Sterility (keterangan: ada di ClinicalKey) vol. 92 no. 01 (Jul. 2009), page 163-169.
Topik: Luteal phase support; IVF; ART; vaginal progesterone; meta-analysis; intramuscular progesterone; hormone replacement therapy

Ketersediaan

Perpustakaan FK Nomor Panggil: F02.K.2009.03 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

Lihat Detail Induk

Isi artikel

Objective : To perform an analysis of data with consideration for the current clinically accepted vaginal progesterone (P) or intramuscular (IM) P dosing regimens and the clinically relevant randomized clinical trials published during the time frame 1992 to 2008. Design : Meta-analysis of progesterone luteal support in IVF cycles using odds ratios (OR) and 95% confidence intervals (CI). Setting : Previously conducted randomized clinical trials meeting acceptance criteria. Patient(s) : Infertility patients. Intervention(s) : Progesterone (50 mg) IM daily or 200 mg P-in-oil capsules three times a day vaginally or 90 mg P in bioadhesive gel daily vaginally. Main Outcome Measure(s) : Clinical pregnancy, ongoing pregnancy, miscarriage. Result(s) : This analysis showed a comparable effect between vaginal progesterone as an oil-in-capsule or as a bioadhesive gel and IM P administration on the endpoints of clinical pregnancy (OR = 0.91, 95% [CI 0.74, 1.13]) and ongoing pregnancy (OR = 0.94, 95% [CI 0.71, 1.26]). A nominally significantly lower rate of miscarriage was observed with vaginal P compared with IM P (OR = 0.54, 95% [CI 0.29, 1.02]). Conclusion(s) : Administration of vaginal P is comparable to administration of IM P for luteal phase support in assisted reproductive technology.

Opini Anda

Klik untuk menuliskan opini Anda tentang koleksi ini!

Kembali