Selection of patients for natural cycle in vitro fertilization combined with in vitro maturation of immature oocytes  

Oleh:

Jin-Ho, Lim ; Seong-Ho, Yang ; Ye, Xu ; San-Hyun, Yoon ; Ri-Cheng, Chian

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: Fertility and Sterility (keterangan: ada di ClinicalKey) vol. 91 no. 04 (Apr. 2009), page 1050-1055.
Topik: Natural cycle; IVF; IVM; oocytes; pregnancy

Ketersediaan

Perpustakaan FK Nomor Panggil: F02.K.2009.01 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

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Isi artikel

Objective : To determine a successful method of selecting patients for natural cycle IVF combined with in vitro maturation (IVM) of immature oocytes and to determine treatment efficacy. Design : Retrospective analysis of IVF treatments. Setting : Hospital IVF clinic. Patient(s) : Women with infertility according to ovarian reserve and endocrine profile were selected for different treatments. Interventions(s) : According to screening criteria, infertile women were divided into three treatments: [1] natural cycle IVF combined with IVM (IVF/M), [2] IVM alone, and [3] controlled ovarian hyperstimulation (COH) with gonadotropin. Main Outcome Measure(s) : The distribution of completed IVF–ET cycles in each treatment; clinical pregnancy and implantation rates in each treatment. Result(s) : A total of 417 cycles were started, and 410 cycles (98.3%) were completed. Of 410 cycles, 151 (36.8%) were treated by natural cycle IVF/M, 63 (15.4%) underwent IVM alone, and 196 (47.8%) underwent COH. With increasing age fewer cycles can be treated by natural cycle IVF/M or IVM. Clinical pregnancy rates were 40.4% (61 of 151) for natural cycle IVF/M, 41.3% (26 of 63) for IVM alone, and 37.8% (74 of 196) for COH. There were no differences in implantation rate in the three groups (17.8% [82 of 462], 16.7% [35 of 210], and 20.1% [103 of 513]). Conclusion(s) : Natural cycle IVF/M together with IVM-alone treatment can offer more than 50% of infertile women with an acceptable pregnancy and implantations rates.

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