Luteal phase estradiol level: a potential predictive marker for successful pregnancy in in vitro fertilization/intracytoplasmic sperm injection  

Oleh:

Ganesh, Ashalatha ; Goswami, Sourendrakant ; Chattopadhyay, Ratna ; Chakraborty, Chandan ; Chaudhury, Koel ; Chakravarty, Baidya Nath

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: Fertility and Sterility (keterangan: ada di ClinicalKey) vol. 91 no. 04 (Apr. 2009), page 1018-1022.
Topik: Luteal phase; estradiol; FSH; progesterone; pregnancy

Ketersediaan

Perpustakaan FK Nomor Panggil: F02.K.2009.01 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

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Isi artikel

Objective : To analyze the role of luteal E2, P, and FSH levels in the prediction of clinical pregnancy in stimulated cycles. Design : Prospective study. Setting : Institute of Reproductive Medicine, Salt Lake, Kolkata, India. Patient(s) : A total of 268 women aged <40 years undergoing their first IVF-ET/intracytoplasmic sperm injection cycles. Intervention(s) : Estimation of luteal phase serum E2, P, and FSH levels on days 0, 7, and 14 of ET. Main Outcome Measure(s) : Comparison of luteal phase hormonal profile in pregnant and nonpregnant women and interpretation by discriminant analysis. Result(s) : A total of 113 pregnancies were achieved (42.16%). Age, basal FSH level, peak E2 level, number of oocytes retrieved, and number of embryos transferred were comparable between pregnant and nonpregnant women. Day-7 and day-14 luteal E2 levels were significantly different between the two groups. Progesterone levels were comparable in both groups on days 0 and 14. Levels of FSH showed statistically significant differences between the two groups on days 0, 7, and 14. Classification accuracy for E2, P, and FSH was 82.1%, 60.8%, and 67.51%, respectively. Conclusion(s) : Luteal E2 concentration seems to be a promising marker of successful clinical pregnancy.

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