Xanthones from Mangosteen Prevent Lipopolysaccharide-Mediated Inflammation and Insulin Resistance in Primary Cultures of Human Adipocytes  

Oleh:

Bumrungpert, Akkarach ; Kalpravidh, Ruchaneekorn W. ; Chitchumroonchokchai, Chureeporn

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: JN: The Journal of Nutrition vol. 139 no. 06 (Jun. 2009), page 1185-1191.
Topik: Nutritional Immunology

Ketersediaan

Perpustakaan FK Nomor Panggil: J42.K.2009.02 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

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Isi artikel

The xanthones, - and -mangostin (MG), are major bioactive compounds found in mangosteen and are reported to have antiinflammatory properties in several murine models. Given the association between obesity, chronic low-grade inflammation, and insulin resistance, we examined the effects of - and -MG on markers of inflammation and insulin resistance in primary cultures of newly differentiated human adipocytes treated with lipopolysaccharide (LPS). - and -MG decreased the induction by LPS of inflammatory genes, including tumor necrosis factor- , interleukin (IL)-1ß, IL-6, IL-8, monocyte chemoattractant protein-1, and Toll-like receptor-2. Moreover, - and -MG attenuated LPS activation of the mitogen-activated protein kinases (MAPK) c-jun NH2-terminal kinase, extracellular signal-related kinase, and p38. - and -MG also attenuated LPS activation of c-Jun and activator protein (AP)-1 activity. -MG was more effective than -MG on an equimolar basis. Furthermore, -MG but not -MG attenuated LPS-mediated I B- degradation and nuclear factor- B (NF- B) activity. In addition, -MG prevented the suppression by LPS of insulin-stimulated glucose uptake and PPAR- and adiponectin gene expression. Taken together, these data demonstrate that MG attenuates LPS-mediated inflammation and insulin resistance in human adipocytes, possibly by inhibiting the activation of MAPK, NF- B, and AP-1.

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