The p21 codon 31*C- and DRD2 codon 313*T-related genotypes/alleles, but not XRCC1 codon 399, hOGG1 codon 326, and DRD1-48 polymorphisms, are correlated with the presence of leiomyoma  

Oleh:

Yao-Yuan, Hsieh ; Chi-Chen, Chang ; Da-Tian, Bau ; Fuu-Jen, Tsai

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: Fertility and Sterility (keterangan: ada di ClinicalKey) vol. 91 no. 03 (Mar. 2009), page 869-877 .
Topik: DRD; hOGG1; leiomyoma; p21; polymorphism; XRCC1

Ketersediaan

Perpustakaan FK Nomor Panggil: F02.K.2009.01 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

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Isi artikel

Objective To investigate whether the gene polymorphisms for p21, X-ray repair cross-complementing group 1 (XRCC1), human 8-oxoguanine glycosylase 1 (hOGG1), and dopamine D1 and D2 receptors (DRD1, -2) are associated with leiomyoma susceptibility. Design Prospective study. Setting Departments of gynecology and genetics in a medical center. Patient(s) Women were divided into two groups: leiomyoma (n = 120) and nonleiomyoma (n = 112). Intervention(s) The p21 codon 31, XRCC1 codon 399, hOGG1 codon 326, DRD1-48, and DRD2 codon 313 polymorphisms were genotyped by polymerase chain reaction with restriction enzyme digestions (Blp I, MspI, Fnu4HI, Dde I, and NcoI, respectively). Main Outcome Measure(s) Genotypes and allelic frequencies. Result(s) The p21 codon 31*C- and DRD2 codon 313*T-related genotypes/alleles were associated with the presence of leiomyomas. The proportions of p21*CC/CA/AA and DRD2*CC/CT/TT in both groups were 27.5/68.3/4.2% and 12.5/51.7/35.8% (leiomyoma); and 14.3/51.8/33.9% and 33.9/40.2/25.9% (nonleiomyoma). XRCC1, hOGG1, and DRD1 were not correlated with the presence of leiomyomas. XRCC1*GG/GA/AA, hOGG1*TT/TA/AA, and DRD1*GG/GA/AA were 54.2/37.5/8.3%, 36.7/44.2/19.1%, and 3.3/25.8/70.8% (leiomyoma); and 48.2/47.3/4.5%, 43.6/41/15.4%, and 3.6/25/71.4% (nonleiomyoma). Conclusion(s) The p21 codon 31*C- and DRD2 codon 313*T-related genotypes/alleles were associated with the presence of leiomyoma. XRCC1, hOGG1, and DRD1 were not correlated with leiomyoma development.

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