Discrete-Event Models Of Mixed-Phenotype Plasmodium Falciparum Malaria  

Oleh:

McKenzie, F. Ellis ; Wong, Roger C. ; Bossert, William H.

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: Simulation vol. 73 no. 4 (Apr. 1997), page 213-217.
Topik: Epidemiology; infectious disease; malaria; population biology; prevalence; transmission; vector
Fulltext: 213.pdf (551.84KB)

Isi artikel

We extend our basic discrete-event model of Plasmodium falciparum malaria to encompass circumstances in which multiple phenotypic variants of the parasite circulate within interacting human and mosquito populations, and we compare a version in which variants behave independently to one in which they interact through shared host immune responses. Relative to the standard hypothesis of statistical independence, frequencies of mixed-phenotype infection in humans were as expected in the independent-immunity version and much less than expected in the cross-immunity version; in both versions, however, such frequencies in mosquitoes were much greater than expected.

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