The Effects Of Protease Inhibitors On The Spread Of HIV And The Development Of Drug-Resistant HIV Strains: A Simulation Study  

Oleh:

Zaric, Gregory S. ; Brandeau, Margaret L. ; Bayoumi, Ahmed M. ; Owens, Douglas K.

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: Simulation vol. 71 no. 4 (Apr. 1995), page 262-275.
Topik: Biology; operations research; HIV; AIDS; drug-resistant HIV; Excel
Fulltext: 262.pdf (1.28MB)

Isi artikel

Recent advances in the development of protease inhibitors offer the promise of significantly longer lives for many HIV-infected individuals. However, the drug dosing regimens are often difficult for patients to follow, and non-compliance can enhance the development of drug-resistant strains of HIV. This paper uses computer simulation to analyze the effects of such "multidrug therapy" and treatment compliance on the spread of HIV and of multi-drug-resistant HIV strains. The analysis is based on a dynamic compartmental model of the epidemic simulated using Excel, a spreadsheet package. Our analysis shows that multi-drug therapy can lead to significantly high prevalence of multi-drugresistant HIV strains. Even under optimistic assumptions about rates of compliance and rates at which drug resistance develops, the development of multi-drugresistant HIV strains in the population may be significant. Our analysis shows that the most important factors affecting the development of multi-drug-resistant HIV strains are initial and continuing compliance with treatment. New treatments that are easier to comply with or behavioral interventions that increase patients’ compliance could significantly reduce the spread of multi-drug-resistant HIV strains.

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