Poor sperm quality affects clinical outcomes of intracytoplasmic sperm injection in fresh and subsequent frozen–thawed cycles: potential paternal effects on pregnancy outcomes  

Oleh:

Sun-Hee, Lee ; Haengseok, Song ; Yong-Seog, Park

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: Fertility and Sterility (keterangan: ada di ClinicalKey) vol. 91 no. 03 (Mar. 2009), page 798-804.
Topik: Defective spermatogenesis; paternal effect; clinical outcomes; ICSI; fresh ET; frozen-thawed ET

Ketersediaan

Perpustakaan FK Nomor Panggil: F02.K.2009.01 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

Lihat Detail Induk

Isi artikel

Objective To evaluate objectively whether poor sperm quality affects sequential events from fertilization to delivery in fresh intracytoplasmic sperm injection (ICSI) and subsequent frozen–thawed embryo transfer (ET) cycles. Design Retrospective study. Setting University-based centers for reproductive medicine. Patient(s) For unbiased comparison, 206 cycles were chosen from 1,999 cycles of patients who underwent ICSI-ET and/or subsequent frozen–thawed ET. Cycles met the following criteria: day 3 ET; female age, <40 y; number of retrieved oocytes, =5; no split insemination; and no female factors but tubal factor. Intervention(s) None. Main Outcome Measure(s) The rates of fertilization, embryo implantation, clinical pregnancy, and delivery and sequential embryonic score (SES) were compared between normal-spermatogenesis patients (NSPs) and defective-spermatogenesis patients (DSPs). Result(s) Although sum SES, mean SES, and top SES of transferred embryos on day 3 were similar between NSPs and DSPs, the rates of implantation, clinical pregnancy, and delivery of NSPs were significantly higher than those of DSPs. Furthermore, subsequent ET cycles with frozen–thawed embryos in NSPs and DSPs who failed to achieve pregnancy in their fresh cycles showed that rates of implantation and clinical pregnancy also were significantly lower in DSPs. Conclusion(s) Quality of sperm may influence embryo implantation and subsequent pregnancy outcomes without impairment of embryo quality.

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