Acute Promyelocytic Leukemia — Weapons of Mass Differentiation  

Oleh:

Licht, Jonathan D.

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: The New England Journal of Medicine (keterangan: ada di Proquest) vol. 360 no. 09 (Feb. 2009), page 928.

Ketersediaan

Perpustakaan FK Nomor Panggil: N08.K.2009.01 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

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Isi artikel

Acute myeloid leukemia (AML) involves the immortalization of immature myeloid progenitors and is a heterogeneous disease. Current clinical practice separates AML into low-, intermediate-, and high-risk categories according to cytogenetic anomalies. Among the low-risk subtypes of AML is acute promyelocytic leukemia (APL). Approximately 98% of persons with APL carry a translocation of chromosomes 15 and 17, typically resulting in the fusion between RAR (retinoic acid receptor ), which encodes a retinoic acid receptor, and the promyelocytic leukemia (PML) protein. These persons are treated with all-trans retinoic acid in combination with chemotherapy; this treatment results in prolonged remission in more . . .

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