The Will-o'-the-Wisp of Genetics — Hunting for the Azoospermia Factor Gene  

Oleh:

Tyler-Smith, Chris ; Krausz, Csilla

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: The New England Journal of Medicine (keterangan: ada di Proquest) vol. 360 no. 09 (Feb. 2009), page 925.

Ketersediaan

Perpustakaan FK Nomor Panggil: N08.K.2009.01 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

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Isi artikel

It has been known for decades that the Y chromosome carries genes required for spermatogenesis and male fertility. But it has been frustratingly difficult to pin down the relevant genes, to such an extent that a finding reported by Luddi et al.1 in this issue of the Journal — that the ubiquitin-specific peptidase 9, Y-linked gene (USP9Y) is not essential for normal spermatogenesis — represents a noteworthy advance in the field. Approximately 15% of couples have difficulty conceiving; the causes are many and include genetic factors. The most common known genetic causes of spermatogenic failure are karyotype anomalies . . .

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