A luteal estradiol protocol for anticipated poor-responder patients may improve delivery rates  

Oleh:

Hill, Micah J. ; McWilliams, Grant D.E.

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: Fertility and Sterility (keterangan: ada di ClinicalKey) vol. 91 no. 03 (Mar. 2009), page 739-743 .
Topik: Poor responders; IVF outcome; luteal phase; estradiol; embryo morphology; oocytes; pregnancy; microdose flare; GnRH antagonist

Ketersediaan

Perpustakaan FK Nomor Panggil: F02.K.2009.01 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

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Isi artikel

Objective To compare IVF data and outcomes between a standard protocol and a luteal phase E2 protocol. Design Retrospective cohort analysis. Setting(s) Large academic assisted reproduction technologies center. Patient(s) Fifty-seven infertile patients with a history of poor response to IVF stimulation and 228 matched control patients. Intervention(s) IVF with a standard protocol or a luteal phase E2 protocol. Main Outcome Measure(s) Live-birth rates. Result(s) Patients in the luteal E2 protocol required more days of stimulation and total gonadotropins and had higher peak E2 levels when compared with the control group. The luteal E2 protocol showed a greater percentage of embryos with =7 cells on day 3. A trend toward improved delivery rates was seen in the luteal E2 protocol (28.1% vs. 22.4%; relative risk, 1.25, 0.78–2.03). Conclusion(s) A luteal E2 protocol results in improved day 3 embryo development as demonstrated by the percent of embryos at the =7-cell stage. Likewise, the luteal E2 protocol may ultimately improve pregnancy outcomes for patients with poor response to IVF stimulation.

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